Exosomes
Exosomes:
Innovative and disruptive vectors expanding treatment options
In the light of their potential as biomarkers and therapeutic tools, exosomes are gaining increasing interest, especially for disease detection, monitoring and treatment.
Leveraging Naobios’ experience and GMP certification, we are positioned to develop standardized manufacturing processes for these nano-sized vectors. As a full-service CDMO, Naobios offers end-to-end solutions, encompassing process development and optimization (upstream and downstream), GMP manufacturing, analytical development and stringent GMP quality control testing.
Naobios’ affiliation with Clean Cells enables us to extend our services further, covering comprehensive testing services for ATMP characterization.
The production of exosomes
At Naobios, our facilities and technical expertise ensure high-quality services tailored to the specific needs of each partner. Much like virus-based product bioproduction, exosome manufacturing begins with the amplification of a specific cell line of interest in bioreactors. Once stimulated to produce exosomes, the culture medium is collected and undergoes a rigorous purification process, which could involve ultracentrifugation, filtration and chromatography. After purification, the exosomes are quantified and characterized to ensure they meet the required specifications. The resulting drug product is then qualified and delivered with the assurance of quality thanks to our robust in-house quality control services.
Naobios can support exosomes projects to go fast to clinics
With the experience accumulated by the team for more than 20 years on viral-based products, we at Naobios perceive the development and manufacturing of exosomes as a natural extension of our capabilities. It is thus our goal to expand activities in this field, sustained by our strict segregation policies and cleaning procedures.
In this short video, discover how Clean Biologics can support your exosomes drug-candidate project!